Butyl bromide → 3-Butoxy-1-propanol

Temperature

40 °C

Sodium metal (2.13 g) was added by small portions to 1,3-propanediol (15.75 g) and 1-bromobutane (10.3 g) by reference to non-patent reference [J. Am. Chem. Soc. 249 (1939)]. After the addition, the mixture was stirred at 40° C. for 1 hr and further stirred at 60° C. for 1 hr. The precipitated inorganic compound was filtered off, and the filtrate was distilled away under reduced pressure to give the title compound (3.15 g) as a colorless oil.

1. additionAfter the addition
2. stirringfurther stirred at 60° C. for 1 hr
3. filtrationThe precipitated inorganic compound was filtered off
4. distillationthe filtrate was distilled away under reduced pressure

ORD record

ord-4dd22f2ef1fe43528eb42b8181640343

Source dataset

uspto-grants-2011_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08026370B2