Trifluoroacetic acid → HCID 59759220, compound

HRID 914515Notes

Reaction equation

HRID 914515 reaction equation
[C:1]([CH2:4][C:5]1[N:6]=[C:7]([S:10][C:11]([CH3:16])([CH3:15])[C:12]([OH:14])=[O:13])[S:8][CH:9]=1)(O)=O.[NH2:17][C:18]1[CH:19]=[C:20]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:21]=[CH:22][CH:23]=1.FC(F)(F)C(O)=O>>[C:20]1([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:21]=[CH:22][CH:23]=[C:18]([NH:17][CH2:1][CH2:4][C:5]2[N:6]=[C:7]([S:10][C:11]([CH3:16])([CH3:15])[C:12]([OH:14])=[O:13])[S:8][CH:9]=2)[CH:19]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 167173-AminobiphenylHCID 67399201HCID 67399201, compound

Product 1

HCID 59759220HCID 59759220, compound

Procedure

Operations similar to Example 520-1 and Example 488-2 were performed using 2-{[4-(carboxymethyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid resin synthesized in Example 461-4 and 3-aminobiphenyl as starting materials. To the obtained resin was added trifluoroacetic acid and the mixture was left standing overnight. The resin was filtered off and the filtrate was concentrated by blowing nitrogen gas thereto, and purified by preparative HPLC to give the title compound (0.015 g) as a pale-brown oil.

Workup

  1. waitthe mixture was left
  2. filtrationThe resin was filtered off
  3. concentrationthe filtrate was concentrated
  4. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-5cd5c2155fe34644b4d0d33d0689a766
Source dataset
uspto-grants-2011_09
Patent number
US08026370B2

Reaction notes

Loading…