Dimethylamine, hydrochloride → HCID 59758875, compound

HRID 914529Notes

Reaction equation

HRID 914529 reaction equation
C([O:5][C:6](=[O:26])[C:7]([S:10][C:11]1[S:12][CH:13]=[C:14]([CH2:16][CH2:17][NH:18][C:19]2[N:24]=[CH:23][C:22](Br)=[CH:21][N:20]=2)[N:15]=1)([CH3:9])[CH3:8])(C)(C)C.Cl[CH2:28][C:29]1[CH:30]=[N:31][N:32]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH:33]=1.Cl.[CH3:41][NH:42][CH3:43]>C(O)(C)(C)C>[CH3:41][N:42]([CH3:43])[C:22]1[CH:23]=[N:24][C:19]([N:18]([CH2:28][C:29]2[CH:30]=[N:31][N:32]([C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[CH:33]=2)[CH2:17][CH2:16][C:14]2[N:15]=[C:11]([S:10][C:7]([CH3:8])([CH3:9])[C:6]([OH:5])=[O:26])[S:12][CH:13]=2)=[N:20][CH:21]=1

Participants

5

Reactant 3

HCID 10473Dimethylamine, hydrochlorideHCID 21211624-(chloromethyl)-1-phenyl-1H-pyrazoleHCID 597588042-[(4-{2-[(5-Bromopyrimidin-2-yl)amino]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester

Product 1

HCID 59758875HCID 59758875, compound

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

An operation similar to that of Example 442-1 was performed using 2-[(4-{2-[(5-bromopyrimidin-2-yl)amino]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester synthesized in Example 162-1 and 4-(chloromethyl)-1-phenyl-1H-pyrazole synthesized in Reference Example 18 as starting materials. An operation similar to that of Example 442-2 was performed (solvent was changed to tert-butanol) using the obtained compound and dimethylamine hydrochloride as starting materials. The obtained compound was subjected to an operation similar to that of Example 442-3 to give the title compound.

Workup

  1. customsynthesized in Reference Example 18

Sources & evidence

ORD record
ord-2d7893106f344ee4856b0053eed2f2c1
Source dataset
uspto-grants-2011_09
Patent number
US08026370B2

Reaction notes

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