Bromoacetyl bromide → HCID 10636022, compound

HRID 914698Notes

Reaction equation

HRID 914698 reaction equation
[Br:1][CH2:2][C:3]([N:5]([CH:12]([CH3:14])[CH3:13])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4].[F:15]C1C=CC(NC(C)C)=CC=1.BrCC(Br)=O>>[Br:1][CH2:2][C:3]([N:5]([C:6]1[CH:11]=[CH:10][C:9]([F:15])=[CH:8][CH:7]=1)[CH:12]([CH3:14])[CH3:13])=[O:4]

Participants

4

Reactant 3

HCID 61147Bromoacetyl bromideHCID 154403Benzenamine, 4-fluoro-N-(1-methylethyl)-HCID 152160012-bromo-N-isopropyl-N-phenyl-acetamide

Product 1

HCID 10636022HCID 10636022, compound

Procedure

Following the procedure described for Preparation 1(A); (4-fluoro-phenyl)-isopropyl-amine (13.70 g, 89.54 mmol) was alkylated with bromoacetyl bromide (7.78 mL, 89.54 mmol) to provide 15.02 g of 2-bromo-N-(4-fluoro-phenyl)-N-isopropyl-acetamide as an oil. 1H NMR (CD2Cl2) δ 7.14-7.23 (m, 4H), 4.90 (m, 1H), 3.53 (s, 2H), 1.05 (d, 6H).

Sources & evidence

ORD record
ord-2896178e4d89489f8c5342292e8c9f76
Source dataset
uspto-grants-2007_09
Patent number
US07265104B2

Reaction notes

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