Hydrochloric Acid → HCID 69143472, compound

HRID 914767Notes

Reaction equation

HRID 914767 reaction equation
C([NH:8][C@@H:9]([C:13]([N:15]1[CH2:20][CH2:19][CH:18]([CH:21]2[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]2)[CH2:17][CH2:16]1)=[O:14])[CH:10]([CH3:12])[CH3:11])(OC(C)(C)C)=O.[ClH:28]>CO>[ClH:28].[ClH:28].[NH2:8][C@@H:9]([C:13]([N:15]1[CH2:20][CH2:19][CH:18]([CH:21]2[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]2)[CH2:17][CH2:16]1)=[O:14])[CH:10]([CH3:11])[CH3:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69141286HCID 69141286, compound

Product 1

HCID 69143472HCID 69143472, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

1-(Boc-D-Valinyl)-4-(1-methylpiperidin-4-yl)piperidine (23.3 g, 61.1 mmol) is dissolved in anhydrous methanol (700 mL), cooled to 0° C. and treated with HCl (gas) until HPLC indicates consumption of starting material is complete. The solvent is removed in vacuo to give 20.8 g (96%) of the title compound as an off-white foam.

Workup

  1. customconsumption of starting material
  2. customThe solvent is removed in vacuo

Sources & evidence

ORD record
ord-21c267d4b16a4338980fce84f268d3f2
Source dataset
uspto-grants-2007_09
Patent number
US07265121B2

Reaction notes

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