反应详情

A solution of 8 (1.15 g) in 6N HCl (10 mL) was heated at 60° C. for 4 hours. After cooling to room temperature, the solution was neutralized with 6N NaOH solution. The aqueous mixture was extracted with EtOAc (2×30 mL), the combined organic layers were washed with brine (1×50 mL) and dried over MgSO4. The solids were filtered, and the filtrate was concentrated under reduced pressure to give the desired product as an oil (0.68 g).

1. extractionThe aqueous mixture was extracted with EtOAc (2×30 mL)
2. washthe combined organic layers were washed with brine (1×50 mL)
3. dry with materialdried over MgSO4
4. filtrationThe solids were filtered
5. concentrationthe filtrate was concentrated under reduced pressure