Methyl iodide → HCID 69332646, compound

HRID 915017Notes

Reaction equation

HRID 915017 reaction equation
[I:1][CH3:2].[NH2:3][C:4]1[N:5]=[C:6]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:7]([C:16]2[CH:17]=[CH:18][C:19](=[O:25])[N:20]([CH:22]([CH3:24])[CH3:23])[N:21]=2)=[N:8][C:9]=1[C:10]1[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=1>C1COCC1>[I-:1].[NH2:3][C:4]1[C:9]([C:10]2[CH:15]=[CH:14][N+:13]([CH3:2])=[CH:12][CH:11]=2)=[N:8][C:7]([C:16]2[CH:17]=[CH:18][C:19](=[O:25])[N:20]([CH:22]([CH3:24])[CH3:23])[N:21]=2)=[C:6]([C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[N:5]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 69331882HCID 69331882, compound

Product 1

HCID 69332646HCID 69332646, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
30 °C

Procedure

In a sealed tube, iodomethane (0.6 ml) was added to a solution of 6-[5-amino-3-phenyl-6-(4-pyridyl)-2-pyrazinyl]-2-isopropyl-3(2H)-pyridazinone (120 mg) in THF (3 ml) and the mixture was stirred at 25-35° C. for 18 hours. A precipitate was collected by filtration to give 4-[3-amino-6-(1-isopropyl-6-oxo-1,6-dihydro-3-pyridazinyl)-5-phenyl-2-pyrazinyl]-1-methylpyridinium iodide (152 mg).

Workup

  1. filtrationA precipitate was collected by filtration

Sources & evidence

ORD record
ord-c3f28f8a172c41f69a1c0db96dcda120
Source dataset
uspto-grants-2007_09
Patent number
US07265120B2

Reaction notes

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