反应详情

温度

27.5 °C

Under ice-cooling, 12N aq. NaOH (0.9 ml) was added dropwise to a solution of 6-{5-amino-3-phenyl-6-[(trimethylsilyl)ethynyl]-2-pyrazinyl}-2-isopropyl-3(2H)-pyridazinone (908 mg) in a mixture of acetonitrile (0.9 ml) and THF (1.8 ml). The mixture was stirred at 25-30° C. for one hour, neutralized with 6N HCl, extracted with CHCl3, dried over MgSO4 and concentrated under reduced pressure to give a syrup. The syrup was purified by column chromatography on silica gel eluting with a mixture of n-hexane and EtOAc (30:70 v/v) to give 6-(5-amino-6-ethynyl-3-phenyl-2-pyrazinyl)-2-isopropyl-3(2H)-pyridazinone as a solid (196 mg).

1. temperatureUnder ice-cooling
2. extractionextracted with CHCl3
3. dry with materialdried over MgSO4
4. concentrationconcentrated under reduced pressure
5. customto give a syrup
6. customThe syrup was purified by column chromatography on silica gel eluting with a mixture of n-hexane and EtOAc (30:70 v/v)