反应详情

温度

27.5 °C

To a suspension of NaH (60% in oil suspension) (23.3 mg) in 1,2-dimethyl-2-imidazolidinone (0.3 ml) was added 1H-pyrazole (42.3 mg) and the mixture was stirred at 25-30° C. for 30 minutes. After addition of 6-(5-amino-6-bromo-3-phenyl-2-pyrazinyl)-2-isopropyl-3(2H)-pyridazinone (150 mg), the mixture was heated at 120-125° C. for 15 hours. To the reaction mixture was added water (3 ml) to give a precipitate. The precipitate was dissolved in CHCl3, dried over MgSO4 and concentrated under reduced pressure to give a solid. The solid was suspended in acetone and collected by filtration to give 6-[5-amino-3-phenyl-6-(1H-pyrazol-1-yl)-2-pyrazinyl]-2-isopropyl-3(2H)-pyridazinone (66 mg).

1. temperaturethe mixture was heated at 120-125° C. for 15 hours
2. customto give a precipitate
3. dry with materialdried over MgSO4
4. concentrationconcentrated under reduced pressure
5. customto give a solid
6. filtrationcollected by filtration