Sodium Hydroxide → HCID 68874451, compound

HRID 915325Notes

Reaction equation

HRID 915325 reaction equation
[CH2:1]([O:8][C:9]1[CH:37]=[CH:36][C:12]([NH:13][C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[C:21]([C:24]4[O:28][C:27]([CH:29]=[CH:30][C:31]([O:33]CC)=[O:32])=[CH:26][CH:25]=4)[CH:22]=3)[N:17]=[CH:16][N:15]=2)=[CH:11][C:10]=1[Cl:38])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>C1COCC1.C(O)C>[CH2:1]([O:8][C:9]1[CH:37]=[CH:36][C:12]([NH:13][C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[C:21]([C:24]4[O:28][C:27]([CH:29]=[CH:30][C:31]([OH:33])=[O:32])=[CH:26][CH:25]=4)[CH:22]=3)[N:17]=[CH:16][N:15]=2)=[CH:11][C:10]=1[Cl:38])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 68873580HCID 68873580, compound

Product 1

HCID 68874451HCID 68874451, compoundYield 102.4%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Prepared according to Procedure H utilizing ethyl 3-(5-{4-[4-(benzyloxy)-3-chloroanilino]-6-quinazolinyl}-2-furyl)-2-propenoate (0.65 g) and aqueous sodium hydroxide (2M, 4 mL) in THF (8 mL) and ethanol (4 mL) to afford the title compound (0.63 g). Electrospray MS m/z 498 (MH+).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-64932a28429c491ba0dd441e4a7e20d8
Source dataset
uspto-grants-2007_09
Patent number
US07265123B2

Reaction notes

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