Lithium Hydroxide → {6-[5-(4-chloro-phenyl)-2-methyl-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid

HRID 915405Notes

Reaction equation

HRID 915405 reaction equation
C([O:5][C:6](=[O:32])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH2:18][C:19]3[N:20]([CH3:31])[N:21]=[C:22]([C:24]4[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=4)[CH:23]=3)[CH:15]=2)[CH:10]=[CH:9]1)(C)(C)C.[Li+].[OH-]>>[Cl:30][C:27]1[CH:28]=[CH:29][C:24]([C:22]2[CH:23]=[C:19]([CH2:18][O:17][C:14]3[CH:15]=[C:16]4[C:11]([CH:10]=[CH:9][N:8]4[CH2:7][C:6]([OH:32])=[O:5])=[CH:12][CH:13]=3)[N:20]([CH3:31])[N:21]=2)=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 69282513{6-[5-(4-chloro-phenyl)-2-methyl-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester

Product 1

HCID 69280227{6-[5-(4-chloro-phenyl)-2-methyl-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid

Procedure

In analogy to the procedure described for example 1 f], {6-[5-(4-chloro-phenyl)-2-methyl-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester was treated with LiOH to obtain {6-[5-(4-chloro-phenyl)-2-methyl-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid as off-white crystals.

Sources & evidence

ORD record
ord-82fccfe56f454f1fab96aedcdf64b48a
Source dataset
uspto-grants-2007_09
Patent number
US07265149B2

Reaction notes

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