Sodium Iodide → 5-iodomethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole

HRID 915488Notes

Reaction equation

HRID 915488 reaction equation
Cl[CH2:2][C:3]1[N:7]([CH3:8])[N:6]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[CH:4]=1.[I-:19].[Na+]>CC(C)=O>[I:19][CH2:2][C:3]1[N:7]([CH3:8])[N:6]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[CH:4]=1

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 210822245-chloromethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole

Product 1

HCID 692828125-iodomethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

In analogy to the procedure described in example 20 a], 5-chloromethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole (example 9 a]) was treated with sodium iodide in acetone to obtain 5-iodomethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole as yellow solid which was used in the next step without further purification.

Sources & evidence

ORD record
ord-6bf43f8f2469435dbe68adff14dfc595
Source dataset
uspto-grants-2007_09
Patent number
US07265149B2

Reaction notes

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