Methanol → 4-(3,4-Dichlorophenoxy)-1-piperidinebutanoic acid hydrochloride

HRID 915540Notes

Reaction equation

HRID 915540 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][C:21]=1[Cl:22])[O:5][CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][CH2:14][C:15]([O:17]C)=[O:16])[CH2:8][CH2:7]1.CO>Cl>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][C:21]=1[Cl:22])[O:5][CH:6]1[CH2:7][CH2:8][N:9]([CH2:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16])[CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 887MethanolHCID 69417722Methyl 4-(3,4-dichlorophenoxy)-1-piperidinebutanoate

Product 1

HCID 694203114-(3,4-Dichlorophenoxy)-1-piperidinebutanoic acid hydrochlorideYield 180%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Methyl 4-(3,4-dichlorophenoxy)-1-piperidinebutanoate (0.48 g) was dissolved in HCl solution (6M, 10 mL) and methanol (1 mL) was added. The reaction mixture was heated under reflux for 8 days. The solvents were evaporated to give the title compound (0.46 g).

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureunder reflux for 8 days
  3. customThe solvents were evaporated

Sources & evidence

ORD record
ord-3b5aae0d2fa940208c1031a359d17d17
Source dataset
uspto-grants-2007_09
Patent number
US07265227B2

Reaction notes

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