Triethylamine → N-benzoyl-N'-[3-[4-(3,4-dichlorophenoxy)-1-piperidinyl]propyl]-sulfamide

HRID 915545Notes

Reaction equation

HRID 915545 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][C:17]=1[Cl:18])[O:5][CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13]N)[CH2:8][CH2:7]1.[CH2:19]([N:21](CC)CC)C.[C:26]([NH:34][S:35](Cl)(=[O:37])=[O:36])(=[O:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>ClCCl>[C:26]([NH:34][S:35]([NH:21][CH2:19][CH2:13][CH2:12][N:9]1[CH2:8][CH2:7][CH:6]([O:5][C:4]2[CH:15]=[CH:16][C:17]([Cl:18])=[C:2]([Cl:1])[CH:3]=2)[CH2:11][CH2:10]1)(=[O:37])=[O:36])(=[O:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 113582094-(3,4-Dichlorophenoxy)-1-piperidineethanamineHCID 11830956Benzoylsulfamoyl chloride

Product 1

HCID 69420940N-benzoyl-N'-[3-[4-(3,4-dichlorophenoxy)-1-piperidinyl]propyl]-sulfamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-(3,4-Dichlorophenoxy)-1-piperidineethanamine (0.16 g) was dissolved in dichloromethane (2 ml) and triethylamine (88 μl) was added. Benzoylsulfamoyl chloride (0.13 g) was added and the solution was stirred for 16 h. The solvent was evaporated and the residue was purified by HPLC (ammonium acetate: acetonitrile 95% to 5% aq) to give the title compound (6 mg).

Workup

  1. customThe solvent was evaporated
  2. customthe residue was purified by HPLC (ammonium acetate: acetonitrile 95% to 5% aq)

Sources & evidence

ORD record
ord-ecc7985fd6f64511802911b351fe8c2a
Source dataset
uspto-grants-2007_09
Patent number
US07265227B2

Reaction notes

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