Potassium Carbonate → HCID 23073291, compound

HRID 915554Notes

Reaction equation

HRID 915554 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[F:9].[OH:10][C:11]1[C:18]([CH3:19])=[CH:17][C:14]([CH:15]=[O:16])=[CH:13][C:12]=1[CH3:20].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[F:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[CH2:2][O:10][C:11]1[C:12]([CH3:20])=[CH:13][C:14]([CH:15]=[O:16])=[CH:17][C:18]=1[CH3:19]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 67968alpha-Bromo-o-fluorotolueneHCID 752223,5-Dimethyl-4-hydroxybenzaldehyde

Product 1

HCID 23073291HCID 23073291, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

0.5 M Solution of 1-bromomethyl-2-fluoro-benzene (1.50 g, 8.0 mmol) in DMF was added dropwise to a suspension containing 1.09 g of 4-hydroxy-3,5-dimethyl-benzaldehyde (7.3 mmol), 1.51 g of K2CO3 (11 mmol) and 120 mg of KI (0.73 mmol) in 100 ml DMF. The reaction followed the same procedure described in Example 3. The residue was purified on silica gel, obtaining a quantitative recovery of the title compound. (1.88 g)

Workup

  1. customThe residue was purified on silica gel

Sources & evidence

ORD record
ord-dfa5bbbcf36d48768f918ece74edf526
Source dataset
uspto-grants-2007_09
Patent number
US07265244B2

Reaction notes

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