Nitromethane → HCID 68880923, compound

HRID 915903Notes

Reaction equation

HRID 915903 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)[CH:6]=[O:7].[N+:17]([CH3:20])([O-:19])=[O:18]>C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:6]([OH:7])[CH2:20][N+:17]([O-:19])=[O:18])[CH:8]=[CH:9][C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1

Participants

4

Reactant 2

HCID 6375NitromethaneHCID 219565123-Methoxy-4-pyridin-2-ylbenzaldehyde

Product 1

HCID 68880923HCID 68880923, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A THF solution of 3-methoxy-4-pyridin-2-ylbenzaldehyde (0.3 g, 1.4 mmol), nitromethane (0.23 mL, 4.2 mmol) and TEA (0.2 mL, 1.4 mmol) was stirred at 55° C. over night, concentrated and purified on silica gel (2:1 hexane-ethyl acetate) to afford a yellow foam.

Workup

  1. concentrationconcentrated
  2. custompurified on silica gel (2:1 hexane-ethyl acetate)
  3. customto afford a yellow foam

Sources & evidence

ORD record
ord-85023d679afb490d8709e6b26f0f4b41
Source dataset
uspto-grants-2007_09
Patent number
US07268151B2

Reaction notes

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