Tetrahydrofuran → HCID 136342085, compound

HRID 915927Notes

Reaction equation

HRID 915927 reaction equation
O1CCCC1.[CH:6]1([C:12]2[C:20]3[C:19](=[O:21])[NH:18][C:17]([C:22]4[CH:27]=[CH:26][C:25]([N:28]5[CH2:33][CH2:32][CH:31]([OH:34])[CH2:30][CH2:29]5)=[CH:24][C:23]=4[O:35][CH3:36])=[N:16][C:15]=3[N:14]([CH3:37])[N:13]=2)[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.[ClH:38].O1CCOCC1>CCOCC>[ClH:38].[CH:6]1([C:12]2[C:20]3[C:19](=[O:21])[NH:18][C:17]([C:22]4[CH:27]=[CH:26][C:25]([N:28]5[CH2:33][CH2:32][CH:31]([OH:34])[CH2:30][CH2:29]5)=[CH:24][C:23]=4[O:35][CH3:36])=[N:16][C:15]=3[N:14]([CH3:37])[N:13]=2)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 204431481,4-Dioxane hydrochlorideHCID 136005817HCID 136005817, compound

Product 1

HCID 136342085HCID 136342085, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
50 °C

Procedure

A 2 ml tetrahydrofuran suspension of 100 mg (0.23 mmol) of the compound obtained in Example 31 was heated to 50° C. to form a solution. To this solution, 68 μl (0.27 mmol) of a 4M dioxane hydrochloride solution was added. Then, the reaction mixture was brought to room temperature, and ether was added. Precipitated solids were collected by filtration to obtain 96 mg (88%) of the captioned compound.

Workup

  1. customto form a solution
  2. customwas brought to room temperature
  3. customPrecipitated solids
  4. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-9eb83078c0c1494fb72bf324c1f8cc02
Source dataset
uspto-grants-2007_09
Patent number
US07268128B2

Reaction notes

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