Methanesulfonic Acid → HCID 136338917, compound

HRID 915937Notes

Reaction equation

HRID 915937 reaction equation
[CH:1]1([C:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:22]=[CH:21][C:20]([N:23]5[CH2:28][CH2:27][CH:26]([O:29][CH3:30])[CH2:25][CH2:24]5)=[CH:19][C:18]=4[O:31][CH3:32])=[N:11][C:10]=3[N:9]([CH3:33])[N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:34][S:35]([OH:38])(=[O:37])=[O:36]>C(O)C>[CH3:34][S:35]([OH:38])(=[O:37])=[O:36].[CH:1]1([C:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:22]=[CH:21][C:20]([N:23]5[CH2:28][CH2:27][CH:26]([O:29][CH3:30])[CH2:25][CH2:24]5)=[CH:19][C:18]=4[O:31][CH3:32])=[N:11][C:10]=3[N:9]([CH3:33])[N:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 136005929HCID 136005929, compound

Product 1

HCID 136338917HCID 136338917, compoundYield 77.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 1.15 ml ethanol suspended solution of 115 mg (0.255 mmol) of the compound obtained in Example 61 was heated to 60° C. To the system, 17.4 μl (0.267 mmol) of methanesulfonic acid was added, and the temperature of the mixture was gradually lowered to room temperature. Precipitated solids were collected by filtration to obtain 108 mg (77%) of the captioned compound.

Workup

  1. customwas gradually lowered to room temperature
  2. customPrecipitated solids
  3. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-63cb18b581f24be99881c4bdb49ff0eb
Source dataset
uspto-grants-2007_09
Patent number
US07268128B2

Reaction notes

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