反应详情

温度

80 °C

To 5,6-dimethylbenzimidazole-2-thiol (713 mg, 4 mmol) in dimethylformamide (10 ml), triethylamine (836 μl, 6 mmol) and 2-bromomethylbenzonitrile (1176 mg, 6 mmol) were added. After stirring at 80° C. overnight, water was added to the mixture, followed by extraction with ethyl acetate. After the ethyl acetate phase was dried with anhydrous sodium sulfate, it was concentrated and the residue was purified by silica gel column chromatography (hexane:ethyl acetate=3:2) to obtain 2-((5,6-dimethylbenzimidazole-2-ylthio)methyl)benzenecarbonitrile (1159 mg, yield 99%).

1. extractionfollowed by extraction with ethyl acetate
2. dry with materialAfter the ethyl acetate phase was dried with anhydrous sodium sulfate, it
3. concentrationwas concentrated
4. customthe residue was purified by silica gel column chromatography (hexane:ethyl acetate=3:2)