反应详情

To a mixture of 2-(2-chloro-benzylamino)-4-methylene-4,5-dihydro-imidazole-1-carboxylic acid benzyl ester (62.0 mg, 0.17 mmol), 1,5-naphthyridine-6-carboxaldehyde (31.6 mg, 0.2 mmol) and iPrOH (5.0 mL) in a 25-mL round bottom flask was added piperidine (0.05 mL) and the suspension was then heated under refluxing for 3.5 hrs to give a suspension. The reaction mixture was concentrated to give a brown solid which was washed with MeOH and ether. The solid was collected by filtration to give 2-(2-chloro-benzylamino)-5-[1,5]-naphthyridin-2-ylmethylene-1,5-dihydro-imidazol-4-one as a brown solid, (10.1 mg, 16.3%). HR-ES (+) m/e calcd. for C19H14ClN5OS: (M+H)+ 364.0960. Found: 364.0959.

1. temperaturethe suspension was then heated
2. temperatureunder refluxing for 3.5 hrs
3. customto give a suspension
4. concentrationThe reaction mixture was concentrated
5. customto give a brown solid which
6. washwas washed with MeOH and ether
7. filtrationThe solid was collected by filtration