反应详情

To a suspension of 2-amino-4-oxo-4,5-dihydro-imidazole-1-carboxylic acid benzyl ester (46.6 mg, 0.20 mmol), Et3N (26.0 mg, 0.26 mmol) and DMAP (2.5 mg, 0.02 mmol) in CH2Cl2 (4 mL) was added dropwise Ac2O (24.5 mg, 0.24 mmol), and the reaction mixture was then heated to reflux under argon for 1 hr. Cooled to r.t., the reaction mixture was concentrated and the residue was partitioned between EtOAc and water. The organic layer was dried over Na2SO4 and concentrated to give 2-acetylamino-4-oxo-4,5-dihydro-imidazole-1-carboxylic acid benzyl ester as an oil (54.0 mg, 98.2%).

1. temperaturethe reaction mixture was then heated
2. temperatureto reflux under argon for 1 hr
3. concentrationthe reaction mixture was concentrated
4. customthe residue was partitioned between EtOAc and water
5. dry with materialThe organic layer was dried over Na2SO4
6. concentrationconcentrated