反应详情

A solution of 4-(7-azaindol-5-yloxy)-6-benzyloxy-7-methoxyquinazoline (0.36 g, 0.873 mmol), ammonium formate (0.55 g, 8.73 mmol) and 10% palladium on carbon (0.05 g) in DMF (7 ml) containing water (0.3 ml) was stirred at ambient temperature for 1 hour. The mixture was filtered and the filtrate was evaporated. The residue was triturated under diethyl ether and the solid was filtered, washed with ether and dried under vacuum. The solid was triturated under water, filtered, washed with water and dried under vacuum over P2O5 to give 4-(7-azaindol-5-yloxy)-6-hydroxy-7-methoxyquinazoline (0.26 g, 85%).

1. filtrationThe mixture was filtered
2. customthe filtrate was evaporated
3. customThe residue was triturated under diethyl ether
4. filtrationthe solid was filtered
5. washwashed with ether
6. customdried under vacuum
7. customThe solid was triturated under water
8. filtrationfiltered
9. washwashed with water
10. dry with materialdried under vacuum over P2O5