反应详情

温度

85 °C

A mixture of 7-[2-(4-acetylpiperazin-1-yl)ethoxy]-4-chloro-6-methoxyquinazoline (224 mg, 0.61 mmol), (prepared as described for the starting material in Example 28), 5-hydroxy-7-azaindole (91 mg, 0.68 mmol), (prepared as described for the starting material in Example 2), and potassium carbonate (94 mg, 0.68 mmol) in DMA (5 ml) was stirred at 85° C. for 2 hours, allowed to cool to ambient temperature and the solvent evaporated under vacuum. The residue was purified by column chromatography eluting with methylene chloride/methanol (saturated with ammonia) (95/5) to give a white solid. This was triturated with acetone, filtered and dried to give 7-[2-(4-acetylpiperazin-1-yl)ethoxy]-4-(7-azaindol-5-yloxy)-6-methoxyquinazoline (227 mg, 80%).

1. custom(prepared
2. custom(prepared
3. temperatureto cool to ambient temperature
4. customthe solvent evaporated under vacuum
5. customThe residue was purified by column chromatography
6. washeluting with methylene chloride/methanol (saturated with ammonia) (95/5)
7. customto give a white solid
8. customThis was triturated with acetone
9. filtrationfiltered
10. customdried