Hydrochloric Acid → HCID 22350156, compound

HRID 916631Notes

Reaction equation

HRID 916631 reaction equation
[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[C:14]([O:19][CH2:20][CH2:21][NH2:22])[CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:23]>C(OCC)(=O)C.C(OCC)C>[ClH:23].[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[C:14]([O:19][CH2:20][CH2:21][NH2:22])[CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11]2)(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 102678372-[1-(Benzenesulfonyl)indol-4-yl]oxyethanamine

Product 1

HCID 22350156HCID 22350156, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 2-{[1-(phenylsulfonyl)-1H-indole-4-yl]oxy}ethylamine (0.20 g, 0.63 mmol) in ethyl acetate is treated with HCl in diethyl ether (1 M, 0.7 ml) and filtered. The filtercake is dried in vacuo to afford the title product as a pink solid, 0.21 g, mp 198-200° C., identified by NMR and mass spectral analyses.

Workup

  1. filtrationfiltered
  2. customThe filtercake is dried in vacuo

Sources & evidence

ORD record
ord-41cff46e87074643bed8803772750da2
Source dataset
uspto-grants-2007_09
Patent number
US07271180B2

Reaction notes

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