反应详情

温度

40 °C

A mixture of 2-chloro-6-(1H-imidazol-2-yl)-pyridine (800 mg, 4.45 mmol), zinc cyanide (313 mg, 2.68 mmol), Pd2(dba)3 (122 mg, 0.133 mmol), DPPF (144 mg, 0.27 mmol) and water (0.1 mL) in DMF (10 mL) is degassed with argon for 15 minutes. The mixture is then heated at 40° C. overnight in a sealed tube. Solvent is removed and water (30 mL) is added and the mixture is extracted with methylene chloride. On drying (MgSO4), the solvent is removed. Column separation gives the product (172).

1. customis degassed with argon for 15 minutes
2. customSolvent is removed
3. additionwater (30 mL) is added
4. extractionthe mixture is extracted with methylene chloride
5. dry with materialOn drying (MgSO4)
6. customthe solvent is removed
7. customColumn separation