Trifluoroacetic acid → HCID 69494565, compound

HRID 916725Notes

Reaction equation

HRID 916725 reaction equation
C([O:5][C:6](=[O:31])[CH2:7][CH2:8][CH2:9][N:10]1[C:15]2[CH:16]=[CH:17][C:18]([Cl:20])=[CH:19][C:14]=2[C:13]([C:25]#[C:26][CH:27]2[CH2:29][CH2:28]2)([C:21]([F:24])([F:23])[F:22])[O:12][C:11]1=[O:30])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[Cl:20][C:18]1[CH:17]=[CH:16][C:15]2[N:10]([CH2:9][CH2:8][CH2:7][C:6]([OH:31])=[O:5])[C:11](=[O:30])[O:12][C:13]([C:25]#[C:26][CH:27]3[CH2:28][CH2:29]3)([C:21]([F:22])([F:23])[F:24])[C:14]=2[CH:19]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69494573HCID 69494573, compound

Product 1

HCID 69494565HCID 69494565, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 290 mg (0.63 mmol) of 2 was added 6 mL of dichloromethane and 6 mL of trifluoroacetic acid. The reaction mixture was allowed to stir at room temperature for 30 minutes and concentrated under reduced pressure. To the residue was added 40 mL of dichloromethane, which was subsequently concentrated under reduced pressure. The above process of addition of dichloromethane and concentrating under reduced pressure was repeated four more times to give 240 mg (0.59 mmol, 94% yield) of 3 as a thick gum (M+H, 402).

Workup

  1. concentrationconcentrated under reduced pressure
  2. additionTo the residue was added 40 mL of dichloromethane, which
  3. concentrationwas subsequently concentrated under reduced pressure
  4. additionThe above process of addition of dichloromethane
  5. concentrationconcentrating under reduced pressure

Sources & evidence

ORD record
ord-5fcd943f47e04d76a6de3057c133e48b
Source dataset
uspto-grants-2007_09
Patent number
US07271252B2

Reaction notes

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