Carbon tetrabromide → HCID 69385416, compound

HRID 916839Notes

Reaction equation

HRID 916839 reaction equation
[C:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][CH2:12][CH2:13][CH2:14]O)[CH:6]=1)(=[O:3])[CH3:2].C(Br)(Br)(Br)[Br:17].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C(Cl)Cl>[C:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][CH2:12][CH2:13][CH2:14][Br:17])[CH:6]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 68981033HCID 68981033, compound

Product 1

HCID 69385416HCID 69385416, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 3-(4-hydroxybutyl)phenyl acetate (416 mg) in DCM (10 mL) was treated with carbon tetrabromide (1.16 g) and triphenylphosphine (791 mg) and stirred at room temperature for 15 min prior to concentration in vacuo. The residue was purified by chromatography (SPE, DCM-petrol 1:1) to give the title compound. LCMS RT=3.58 min

Workup

  1. concentrationto concentration in vacuo
  2. customThe residue was purified by chromatography (SPE, DCM-petrol 1:1)

Sources & evidence

ORD record
ord-5c0f3dec3e8b4df8aff65ef2f6eb4085
Source dataset
uspto-grants-2007_09
Patent number
US07271197B2

Reaction notes

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