Veratric Acid → HCID 86597249, compound

HRID 917418Notes

Reaction equation

HRID 917418 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[C:6]([OH:8])=O.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CN1CCOCC1.[CH3:45][O:46][C:47]1[C:48]2[N:61]=[C:60]([NH2:62])[S:59][C:49]=2[C:50]([N:53]2[CH2:58][CH2:57][O:56][CH2:55][CH2:54]2)=[N:51][CH:52]=1>C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[C:6]([NH:62][C:60]1[S:59][C:49]2[C:50]([N:53]3[CH2:58][CH2:57][O:56][CH2:55][CH2:54]3)=[N:51][CH:52]=[C:47]([O:46][CH3:45])[C:48]=2[N:61]=1)=[O:8]

Participants

6

Reactant 4

HCID 7121Veratric AcidHCID 79724-MethylmorpholineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 860385537-Methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-ylamine

Product 1

HCID 86597249HCID 86597249, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

From 3,4-dimethoxybenzoic acid, HATU and N-methylmorpholine in THF, then treatment with 7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-ylamine. ES-MS m/e (%): 431 (M+H+, 100).

Sources & evidence

ORD record
ord-645523009cf14d77942080259338af6e
Source dataset
uspto-grants-2007_09
Patent number
US07273865B2

Reaction notes

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