1,3-Benzodioxole-5-carboxylic acid → HCID 11683074, compound

HRID 917419Notes

Reaction equation

HRID 917419 reaction equation
[C:1]([OH:12])(=O)[C:2]1[CH:10]=[CH:9][C:8]2[O:7][CH2:6][O:5][C:4]=2[CH:3]=1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CN1CCOCC1.[CH3:44][O:45][C:46]1[C:47]2[N:60]=[C:59]([NH2:61])[S:58][C:48]=2[C:49]([N:52]2[CH2:57][CH2:56][O:55][CH2:54][CH2:53]2)=[N:50][CH:51]=1>C1COCC1>[CH3:44][O:45][C:46]1[C:47]2[N:60]=[C:59]([NH:61][C:1]([C:2]3[CH:10]=[CH:9][C:8]4[O:7][CH2:6][O:5][C:4]=4[CH:3]=3)=[O:12])[S:58][C:48]=2[C:49]([N:52]2[CH2:53][CH2:54][O:55][CH2:56][CH2:57]2)=[N:50][CH:51]=1

Participants

6

Reactant 4

HCID 71961,3-Benzodioxole-5-carboxylic acidHCID 79724-MethylmorpholineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 860385537-Methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-ylamine

Product 1

HCID 11683074HCID 11683074, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

From piperonylic acid, HATU and N-methylmorpholine in THF, then treatment with 7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-ylamine. ES-MS m/e (%): 415 (M+H+, 100).

Sources & evidence

ORD record
ord-6efa8d5c114c487d8ea626287358dcb9
Source dataset
uspto-grants-2007_09
Patent number
US07273865B2

Reaction notes

Loading…