4-Methylmorpholine → HCID 86597253, compound

HRID 917424Notes

Reaction equation

HRID 917424 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][C:5]([OH:7])=O.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CN1CCOCC1.[CH3:39][O:40][C:41]1[C:42]2[N:55]=[C:54]([NH2:56])[S:53][C:43]=2[C:44]([N:47]2[CH2:52][CH2:51][O:50][CH2:49][CH2:48]2)=[N:45][CH:46]=1>C1COCC1>[CH3:1][O:2][CH2:3][CH2:4][C:5]([NH:56][C:54]1[S:53][C:43]2[C:44]([N:47]3[CH2:52][CH2:51][O:50][CH2:49][CH2:48]3)=[N:45][CH:46]=[C:41]([O:40][CH3:39])[C:42]=2[N:55]=1)=[O:7]

Participants

6

Reactant 4

HCID 79724-MethylmorpholineHCID 1344423-Methoxypropionic acidHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 860385537-Methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-ylamine

Product 1

HCID 86597253HCID 86597253, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

From 3-methoxypropionic acid, HATU and N-methylmorpholine in THF, then treatment with 7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-ylamine. ES-MS m/e (%): 353 (M+H+, 100).

Sources & evidence

ORD record
ord-fd87e38307ca4beeab3b96385f96851c
Source dataset
uspto-grants-2007_09
Patent number
US07273865B2

Reaction notes

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