Diisopropylethylamine → HCID 86597276, compound

HRID 917455Notes

Reaction equation

HRID 917455 reaction equation
C1(O[C:8](=[O:27])[NH:9][C:10]2[S:11][C:12]3[C:13]([N:21]4[CH2:26][CH2:25][O:24][CH2:23][CH2:22]4)=[N:14][CH:15]=[C:16]([O:19][CH3:20])[C:17]=3[N:18]=2)C=CC=CC=1.FC(F)(F)C(O)=O.[CH3:35][C:36]1([CH2:42][OH:43])[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]1.C(N(CC)C(C)C)(C)C>ClC(Cl)C.O1CCCC1>[CH3:20][O:19][C:16]1[C:17]2[N:18]=[C:10]([NH:9][C:8]([N:39]3[CH2:40][CH2:41][C:36]([CH2:42][OH:43])([CH3:35])[CH2:37][CH2:38]3)=[O:27])[S:11][C:12]=2[C:13]([N:21]2[CH2:22][CH2:23][O:24][CH2:25][CH2:26]2)=[N:14][CH:15]=1

Participants

6

Reactant 3

HCID 81531DiisopropylethylamineHCID 22507736(4-Methyl-piperidin-4-yl)-methanol trifluoroacetateHCID 86597258(7-Methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-yl)-carbamic acid phenyl ester

Product 1

HCID 86597276HCID 86597276, compound

Reagents, catalysts & solvents 2

HCID 63651,1-DichloroethaneSolventHCID 8028TetrahydrofuranSolvent

Procedure

From (7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-yl)-carbamic acid phenyl ester with (4-methyl-piperidin-4-yl)-methanol trifluoroacetate and N,N-diisopropylethylamine in dichloroethane and tetrahydrofuran. ES-MS m/e (%): 422 (M+H+, 100).

Sources & evidence

ORD record
ord-45de0d3643ff44d58a4206d99e265d10
Source dataset
uspto-grants-2007_09
Patent number
US07273865B2

Reaction notes

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