反应详情

To a stirred solution of 44 mg (0.31 mmol) 4-fluoro-benzoic acid in 4 ml THF were added 130 mg (0.34 mmol) HATU and 0.068 ml (0.62 mmol) N-methylmorpholine and stirring continued at 50° C. for 16 h. 40 mg (0.16 mmol) 7-methoxy-4-phenyl-thiazolo[5,4-c]pyridin-2-ylamine was then added and stirring continued at 50° C. for 16 h. The reaction mixture was then concentrated in vacuo. Flash chromatography (ethyl acetate/heptane) followed by trituration in ether afforded 7 mg (12%) 4-fluoro-N-(7-methoxy-4-phenyl-thiazolo[5,4-c]pyridin-2-yl)-benzamide as a white crystalline solid. ES-MS m/e (%): 380 (M+H+, 100).

1. stirringstirring
2. waitcontinued at 50° C. for 16 h
3. concentrationThe reaction mixture was then concentrated in vacuo