Hydrochloric Acid → 2-(3-cyanophenylamino)-2-(2-fluorophenyl)-N-[3-methyl-4-(2-oxopiperidin-1-yl)phenyl]acetamide, hydrochloride

HRID 917581Notes

Reaction equation

HRID 917581 reaction equation
[ClH:1].[C:2]([C:4]1[CH:5]=[C:6]([NH:10][CH:11]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[F:35])[C:12]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([N:21]3[CH2:26][CH2:25][CH2:24][CH2:23][C:22]3=[O:27])=[C:17]([CH3:28])[CH:16]=2)=[O:13])[CH:7]=[CH:8][CH:9]=1)#[N:3]>CC(O)C>[ClH:1].[C:2]([C:4]1[CH:5]=[C:6]([NH:10][CH:11]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[F:35])[C:12]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([N:21]3[CH2:26][CH2:25][CH2:24][CH2:23][C:22]3=[O:27])=[C:17]([CH3:28])[CH:16]=2)=[O:13])[CH:7]=[CH:8][CH:9]=1)#[N:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 589627462-(3-cyanophenylamino)2-(2-fluorophenyl)-N-[3-methyl-4-(2-oxopiperidin-1-yl)phenyl]acetamide

Product 1

HCID 1317266092-(3-cyanophenylamino)-2-(2-fluorophenyl)-N-[3-methyl-4-(2-oxopiperidin-1-yl)phenyl]acetamide, hydrochloride

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

1.87 ml of 0.1N HCl in 2-propanol are added to 86 mg (0.187 mmol) of 2-(3-cyanophenylamino)-2-(2-fluorophenyl)-N-[3-methyl-4-(2-oxopiperidin-1-yl)phenyl]acetamide, and the mixture is left to stand at room temperature for 2 hours. The reaction mixture is evaporated and subsequently lyophilised, giving 2-(3-cyanophenylamino)-2-(2-fluorophenyl)-N-[3-methyl-4-(2-oxopiperidin-1-yl)phenyl]acetamide, hydrochloride, as a colourless solid; ESI 460.

Workup

  1. waitthe mixture is left
  2. customThe reaction mixture is evaporated

Sources & evidence

ORD record
ord-3d0e4c96df2d4b6390638d59faf3d3a2
Source dataset
uspto-grants-2007_09
Patent number
US07273867B2

Reaction notes

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