反应详情

温度

80 °C

25 g (208 mmol) of o-tolualdehyde, 14.58 g (208 mmol) of methyl vinyl ketone, 21.05 g (208 mmol) of triethylamine, 5.4 g (21.4 mmol) of 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide were dissolved in this order in 100 ml of DMF and stirred at 80° C. for 12 hours. The reaction mixture was subsequently admixed with 400 ml of water and extracted twice with methylene chloride. The combined methylene chloride phases were washed with 10% strength sulfuric acid and saturated sodium hydrogencarbonate solution and dried over sodium sulfate. After taking off the solvent on a rotary evaporator, the product was purified by fractional distillation.

1. extractionextracted twice with methylene chloride
2. washThe combined methylene chloride phases were washed with 10% strength sulfuric acid and saturated sodium hydrogencarbonate solution
3. dry with materialdried over sodium sulfate
4. customon a rotary evaporator
5. distillationthe product was purified by fractional distillation