Allyl bromide → HCID 23630904, compound

HRID 917735Notes

Reaction equation

HRID 917735 reaction equation
[F:1][C:2]1[CH:20]=[C:19]([I:21])[CH:18]=[CH:17][C:3]=1[NH:4][C:5]1[C:6]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:7][NH:8][C:9](=[O:11])[CH:10]=1.[H-].[Na+].[CH2:24](Br)[CH:25]=[CH2:26]>CN(C=O)C>[CH2:26]([N:8]1[C:9](=[O:11])[CH:10]=[C:5]([NH:4][C:3]2[CH:17]=[CH:18][C:19]([I:21])=[CH:20][C:2]=2[F:1])[C:6]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:7]1)[CH:25]=[CH2:24]

Participants

5

Reactant 3

HCID 7841Allyl bromideHCID 24758Sodium hydrideHCID 23630800Ethyl 4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxylate

Product 1

HCID 23630904HCID 23630904, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Ethyl 4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxylate was reacted with NaH and allyl bromide in DMF under the same conditions as for example 22, step A to give a crude solid which was purified by column chromatography on silica gel (50% EtOAc/hexanes as eluant). Ethyl 1-allyl-4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxylate was isolated as a white solid (78%), m.p. (EtOAc) 138-141° C. 1H NMR [(CD3)2SO, 400 MHz] δ 9.30 (s, 1H), 8.45 (s, 1H), 7.77 (dd, J=10.1, 1.9 Hz, 1H), 7.61 (ddd, J=8.4, 2.0, 0.8 Hz, 1H), 7.31 (t, J=8.5 Hz, 1H), 5.98-5.87 (m, 1H), 5.47 (d, J=1.3 Hz, 1H), 5.19 (ddd, J=10.4, 2.7, 1.3 Hz, 1H), 5.12 (ddd, J=17.2, 3.0, 1.5 Hz, 1H), 4.54 (br d, J=5.5 Hz, 2H), 4.31 (q, J=7.1 Hz, 2H), 1.32 (t, J=7.1 Hz, 3H). Anal. Calcd for C17H16FIN2O3: C, 46.2; H, 3.7; N, 6.3. Found: C, 46.5; H, 3.6; N, 6.2.

Workup

  1. customto give a crude solid which
  2. customwas purified by column chromatography on silica gel (50% EtOAc/hexanes as eluant)

Sources & evidence

ORD record
ord-236226ce12344692a29c251c70b5a73a
Source dataset
uspto-grants-2007_09
Patent number
US07273877B2

Reaction notes

Loading…