Tris(hydroxymethyl)aminomethane → HCID 58962841, compound

HRID 917768Notes

Reaction equation

HRID 917768 reaction equation
[F:1][C:2]1[CH:19]=[C:18]([I:20])[CH:17]=[CH:16][C:3]=1[NH:4][C:5]1[C:6]([C:13]([OH:15])=[O:14])=[CH:7][N:8]([CH3:12])[C:9](=[O:11])[CH:10]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[NH2:33][C:34]([CH2:39]O)([CH2:37][OH:38])[CH2:35][OH:36]>C1COCC1.CN(C=O)C>[F:1][C:2]1[CH:19]=[C:18]([I:20])[CH:17]=[CH:16][C:3]=1[NH:4][C:5]1[C:6]([C:13]([O:15][CH2:39][C:34]([NH2:33])([CH2:37][OH:38])[CH2:35][OH:36])=[O:14])=[CH:7][N:8]([CH3:12])[C:9](=[O:11])[CH:10]=1

Participants

5

Reactant 3

HCID 6503Tris(hydroxymethyl)aminomethaneHCID 682631,1'-CarbonyldiimidazoleHCID 112346084-(2-Fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid

Product 1

HCID 58962841HCID 58962841, compoundYield 7%

Reagents, catalysts & solvents 1

HCID 21974620tetrahydrofuran N,N-dimethylformamideSolvent

Procedure

4-(2-Fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid and CDI were dissolved in anhydrous THF/DMF (5:1) and treated with 2-amino-2-[hydroxymethyl]-1,3-propandiol as for example 34. After stirring at RT for 60 h, a precipitate had formed. The solid was isolated by filtration and further purified by flash chromatography on silica gel (5% MeOH/CH2Cl2—10% MeOH/CH2Cl2 gradient elution) to give 2-amino-3-hydroxy-2-(hydroxymethyl)propyl 4-(2-fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate (7%) as a white solid; m.p. (EtOAc/Hexane) 117-122° C. (glue-liquid). 1H NMR [400 MHz, (CD3)2CO] δ 9.44 (br s, 1H), 8.61 (s, 1H), 7.67 (dd, J=9.9, 1.8 Hz, 1H), 7.66-7.62 (m, 1H), 7.35 (dt, J=8.4, 2.4 Hz, 1H), 5.62 (dd, J=6.3, 1.2 Hz, 1H), 4.26 (s, 2H), 3.56 (d, J=1.8 Hz, 4H), 3.49 (s, 3H). HRMS (FAB+) calcd for C17H20FIN3O5 492.0432 (M+), found 492.0450. HPLC 88.9% (254 nm).

Workup

  1. customa precipitate had formed
  2. customThe solid was isolated by filtration
  3. customfurther purified by flash chromatography on silica gel (5% MeOH/CH2Cl2—10% MeOH/CH2Cl2 gradient elution)

Sources & evidence

ORD record
ord-1cae92c624634d309f0875e5d60132a9
Source dataset
uspto-grants-2007_09
Patent number
US07273877B2

Reaction notes

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