Hydrochloric Acid → HCID 178454957, compound

HRID 918033Notes

Reaction equation

HRID 918033 reaction equation
[CH2:1](I)[CH2:2][CH2:3][CH3:4].[SH:6][C:7]1[N:12]=[C:11]([OH:13])[CH:10]=[C:9]([OH:14])[N:8]=1.Cl>[OH-].[Na+]>[CH2:1]([S:6][C:7]1[N:12]=[C:11]([OH:13])[CH:10]=[C:9]([OH:14])[N:8]=1)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 10962Butyl iodideHCID 178516656HCID 178516656, compound

Product 1

HCID 178454957HCID 178454957, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

An amount of 184.1 g of n-butyliodide is added to 144.2 g of 2-mercapto-4,6-dihydroxy-pyrimidine dissolved in 1000 ml of 2-n aqueous sodium hydroxide solution, and the whole heated for 2 hours at 85°-90°C. After cooling, the reaction mixture is rendered acid, to a congo-red indicator, with ice and concentrated hydrochloric acid. The 2-n-butylthio-4,6-dihydroxy-pyrimidine obtained as a precipitate is separated and dried.

Workup

  1. temperaturethe whole heated for 2 hours at 85°-90°C
  2. temperatureAfter cooling

Sources & evidence

ORD record
ord-f427179c64c0477f9812a46b78ab09ab
Source dataset
uspto-grants-1976_07
Patent number
US03969101

Reaction notes

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