反应详情

42.8 gm (0.20 mol) of 4-acetyl-2-fluoro-biphenyl were added in small portions, while stirring, to a Reformatsky reagent prepared from 57.5 gm (0.88 mol) of zinc and 73.5 gm (0.44 mol) of bromoacetic acid ethyl ester in 500 ml of absolute ether/tetrahydrofuran (1:1), and the resulting mixture was refluxed for one hour. Then, 1 liter of water was added, the reaction mixture was acidified with dilute hydrochloric acid, and the organic layer was separated, extracted again with water and dried over sodium sulfate. The raw 3-(2-fluoro-4-biphenylyl)-3-hydroxy-butyric acid ethyl ester remaining after the solvent had been distilled off was refluxed in 330 ml of benzene with 45 gm (0.293 mol) of phosphorus trichloride for 10 minutes, whereupon the solvent was distilled off, water was added to the residue and the precipitated oil was taken up in ether. The ether solution was washed with water and an aqueous 5% sodium bicarbonate solution until neutral, dried, filtered through charcoal, and the solvent was distilled out of the filtrate. The residue, raw 3-(2-fluoro-4-biphenylyl)-2-butenoic acid ethyl ester (39.9 gm, 70% of theory), was used as a starting compound without further purification.

1. temperaturethe resulting mixture was refluxed for one hour
2. customthe organic layer was separated
3. extractionextracted again with water
4. dry with materialdried over sodium sulfate
5. distillationThe raw 3-(2-fluoro-4-biphenylyl)-3-hydroxy-butyric acid ethyl ester remaining after the solvent had been distilled off
6. distillationwas distilled off
7. additionwater was added to the residue
8. washThe ether solution was washed with water
9. dry with materialan aqueous 5% sodium bicarbonate solution until neutral, dried
10. filtrationfiltered through charcoal
11. distillationthe solvent was distilled out of the filtrate
12. customThe residue, raw 3-(2-fluoro-4-biphenylyl)-2-butenoic acid ethyl ester (39.9 gm, 70% of theory), was used as a starting compound without further purification