Metaperiodic acid → HCID 86733755, compound

HRID 918409Notes

Reaction equation

HRID 918409 reaction equation
[Cl:1][CH2:2][C:3](=[O:32])[C@:4]1([OH:31])[C@:21]2([CH3:22])[C@H:7]([C@H:8]3[C@H:18]([C@@H:19]([OH:23])[CH2:20]2)[C@:16]2([CH3:17])[C:11](=[CH:12][C:13](=[O:24])[CH:14]=[CH:15]2)[CH2:10][CH2:9]3)[CH2:6][C@H:5]1[O:25][CH2:26][C:27]1(C)[CH2:29][O:28]1.I(O)(=O)(=O)=O>O1CCCC1.O>[Cl:1][CH2:2][C:3](=[O:32])[C@:4]1([OH:31])[C@:21]2([CH3:22])[C@H:7]([C@H:8]3[C@H:18]([C@@H:19]([OH:23])[CH2:20]2)[C@:16]2([CH3:17])[C:11](=[CH:12][C:13](=[O:24])[CH:14]=[CH:15]2)[CH2:10][CH2:9]3)[CH2:6][C@H:5]1[O:25][CH2:26][C:27](=[O:28])[CH3:29]

Participants

5

Reactant 2

HCID 65185Metaperiodic acidHCID 86733754HCID 86733754, compound

Product 1

HCID 86733755HCID 86733755, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 21-chloro-11β,17-dihydroxy-16α-[(2-methyloxiranyl)methoxy]pregna-1,4-diene-3,20-dione (12 mmoles) in 200 ml of tetrahydrofuran is stirred with a solution of 10 g of periodic acid in 20 ml of water for 3 hours. The slurry is diluted with water and extracted with chloroform. The chloroform solution is dried and evaporated in vacuo to give the title compound.

Workup

  1. extractionextracted with chloroform
  2. dry with materialThe chloroform solution is dried
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-7afbd1b0097c4833841afb56839146d2
Source dataset
uspto-grants-1976_07
Patent number
US03971773

Reaction notes

Loading…