4,7-Dichloroquinoline → 2-(7-Chloro-4-quinolylamino)-3-methyl benzoic acid

HRID 918428Notes

Reaction equation

HRID 918428 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH2:13][C:14]1[C:22]([CH3:23])=[CH:21][CH:20]=[CH:19][C:15]=1[C:16]([OH:18])=[O:17]>Cl>[Cl:12][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH:13][C:14]3[C:22]([CH3:23])=[CH:21][CH:20]=[CH:19][C:15]=3[C:16]([OH:18])=[O:17])=[CH:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 68664,7-DichloroquinolineHCID 781012-Amino-3-methylbenzoic acid

Product 1

HCID 536857712-(7-Chloro-4-quinolylamino)-3-methyl benzoic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

4,7-Dichloroquinoline and 2-amino-3-methyl benzoic acid are refluxed in dilute hydrochloric acid for 1 hour to give 2-(7-chloro-4-quinolylamino)-3-methyl benzoic acid.

Sources & evidence

ORD record
ord-d7ab28be100145f2bb4d44641417554a
Source dataset
uspto-grants-1976_07
Patent number
US03971789

Reaction notes

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