4,7-Dichloroquinoline → 4-Chloro-2-(7-chloro-4-quinolylamino)benzoic acid

HRID 918430Notes

Reaction equation

HRID 918430 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH2:13][C:14]1[CH:22]=[C:21]([Cl:23])[CH:20]=[CH:19][C:15]=1[C:16]([OH:18])=[O:17]>Cl>[Cl:23][C:21]1[CH:20]=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[C:14]([NH:13][C:2]2[C:11]3[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=3)[N:5]=[CH:4][CH:3]=2)[CH:22]=1

Participants

4

Reactant 2

HCID 68664,7-DichloroquinolineHCID 666462-Amino-4-chlorobenzoic acid

Product 1

HCID 215210034-Chloro-2-(7-chloro-4-quinolylamino)benzoic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

4,7-Dichloroquinoline and 2-amino-4-chloro benzoic acid are refluxed in dilute hydrochloric acid for 1 hour to give 4-chloro-2-(7-chloro-4-quinolylamino)benzoic acid.

Sources & evidence

ORD record
ord-56ac0d86bded4971a0473ad1ca6612e0
Source dataset
uspto-grants-1976_07
Patent number
US03971789

Reaction notes

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