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HRID918608

反应详情

EQUATION

反应方程式

HRID 918608 的结构方程式

REACTANTS

反应物

3
结构：Oc1cccc(Cl)c1
HCID7933

3-Chlorophenol

C6H5ClO

结构：NS(=O)(=O)c1cc(C(=O)O)cc([N+](=O)[O-])c1Cl
HCID89893

4-Chloro-3-nitro-5-sulphamoylbenzoic acid

C7H5ClN2O6S

结构：O=C([O-])O.[Na+]
HCID516892

Sodium Bicarbonate

CHNaO3

PRODUCTS

生成物

1
结构：NS(=O)(=O)c1cc(C(=O)O)cc([N+](=O)[O-])c1Oc1cccc(Cl)c1
HCID21506084

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

CONDITIONS

反应条件

温度
85 °C

PROCEDURE

实验过程

A mixture of 4-chloro-3-nitro-5-sulphamyl-benzoic acid (28 g), m-chlorophenol (26 g), sodium bicarbonate (34 g), and water (200 ml) was stirred at 85°C for 10 hours. After cooling, excess m-chlorophenol was removed by extraction with diethyl ether, and 4-(m-chlorophenoxy)-3-nitro-5-sulphamyl-benzoic acid was precipitated from the aqueous layer by the addition of 4N hydrochloric acid. After recrystallization from aqueous methanol, the melting point was 230°-232°C.

WORKUP

后处理

  1. temperatureAfter cooling
  2. customexcess m-chlorophenol was removed by extraction with diethyl ether, and 4-(m-chlorophenoxy)-3-nitro-5-sulphamyl-benzoic acid
  3. customwas precipitated from the aqueous layer by the addition of 4N hydrochloric acid
  4. customAfter recrystallization from aqueous methanol