Hydrochloric Acid → HCID 21506045, compound

HRID 918647Notes

Reaction equation

HRID 918647 reaction equation
C([O:3][C:4](=[O:26])[C:5]1[CH:10]=[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])[C:8]([NH:15][C:16]2[N:21]=[C:20]([CH3:22])[CH:19]=[CH:18][CH:17]=2)=[C:7]([N+:23]([O-:25])=[O:24])[CH:6]=1)C.O.Cl>[OH-].[Na+]>[CH3:22][C:20]1[CH:19]=[CH:18][CH:17]=[C:16]([NH:15][C:8]2[C:9]([S:11](=[O:13])(=[O:14])[NH2:12])=[CH:10][C:5]([C:4]([OH:26])=[O:3])=[CH:6][C:7]=2[N+:23]([O-:25])=[O:24])[N:21]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 21506066HCID 21506066, compound

Product 1

HCID 21506045HCID 21506045, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Ethyl-4-(2-methyl-6-pyridylamino)-3-nitro-5-sulphamyl-benzoate (2 g) was dissolved in 1N sodium hydroxide (30 ml) and heated on a steam bath for 1 hour. After cooling, water (50 ml) was added, and the pH of the reaction mixture was adjusted to 4.5 by addition of 1N hydrochloric acid. The precipitated 4-(2-methyl-6-pyridylamino)-3-nitro-5-sulphamyl-benzoic acid was collected by suction, washed with water, and dried. The compound had a melting point of 305°C (decomp.).

Workup

  1. temperatureheated on a steam bath for 1 hour
  2. temperatureAfter cooling
  3. customThe precipitated 4-(2-methyl-6-pyridylamino)-3-nitro-5-sulphamyl-benzoic acid was collected by suction
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-0fa406baf52941f89afb15887003949e
Source dataset
uspto-grants-1976_07
Patent number
US03971819

Reaction notes

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