Methylamine → HCID 86346165, compound

HRID 918755Notes

Reaction equation

HRID 918755 reaction equation
CO[C:3](=[O:25])/[C:4](=[N:22]/[O:23][CH3:24])/[C:5](/[CH3:21])=[CH:6]\[CH2:7][O:8][C:9]1[CH:13]=[CH:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[N:10]=1.[CH3:26][NH2:27]>C1COCC1.O>[CH3:26][NH:27][C:3](=[O:25])/[C:4](=[N:22]/[O:23][CH3:24])/[C:5](/[CH3:21])=[CH:6]\[CH2:7][O:8][C:9]1[CH:13]=[CH:12][N:11]([C:14]2[CH:15]=[CH:16][C:17]([Cl:20])=[CH:18][CH:19]=2)[N:10]=1

Participants

5

Reactant 2

HCID 6329MethylamineHCID 89661875HCID 89661875, compound

Product 1

HCID 86346165HCID 86346165, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent2×

Procedure

120 mg (0.33 mmol) (Z)-5-[1-(4-chloro-phenyl)-1H-pyrazol-3-yloxy]-2-[(E)-methoxyimino]-3-methyl-pent-3-enic acid methyl ester and 0.99 ml (1.98 mmol) of a 2-molar solution of methyl amine in THF have been stirred overnight at ambient temperature in 2.0 ml of THF and 0.5 ml of water. After removal of the solvent in vacuo the product (120 mg) was collected in quantitative yield and good purity. Melting point 129-130° C.

Workup

  1. customAfter removal of the solvent in vacuo the product (120 mg)
  2. customwas collected in quantitative yield and good purity

Sources & evidence

ORD record
ord-8b9ec03df2274b898f3082e950bcac66
Source dataset
uspto-grants-2016_03
Patent number
US09271501B2

Reaction notes

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