Sodium Thiosulfate → HCID 118020287, compound

HRID 918789Notes

Reaction equation

HRID 918789 reaction equation
[CH2:1]([S:3]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12](=[O:14])[CH3:13])(=[O:5])=[O:4])[CH3:2].[Br-:15].[Br-].[Br-].C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.S([O-])([O-])(=O)=S.[Na+].[Na+]>C1COCC1>[Br:15][CH2:13][C:12]([C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[S:3]([CH2:1][CH3:2])(=[O:5])=[O:4])=[O:14]

Participants

5

Reactant 3

HCID 24477Sodium ThiosulfateHCID 17977687Phenyltrimethylammonium bromide dibromideHCID 118020273HCID 118020273, compound

Product 1

HCID 118020287HCID 118020287, compoundYield 164%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 1.0 g of 2′-ethylsulfonylacetophenone, 1.86 g of phenyltrimethylammonium tribromide and 10 ml of THF was stirred at room temperature for 3 hours. A 10% aqueous sodium thiosulfate solution was poured to the reaction mixture, and the mixture was extracted with t-butyl methyl ether. The organic layer was washed with water and dried over anhydrous magnesium sulfate, then concentrated under reduced pressure to obtain 1.37 g of 2-bromo-2′-ethylsulfonylacetophenone.

Workup

  1. extractionthe mixture was extracted with t-butyl methyl ether
  2. washThe organic layer was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-a4113293249a4635ab0350ec192b987b
Source dataset
uspto-grants-2016_03
Patent number
US09271500B2

Reaction notes

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