反应详情

温度

80 °C

(3-Bromo-pyridin-4-yl)-carbamic acid 1-(2-chloro-phenyl)-ethyl ester (0.180 g, 0.51 mmol), 4-hydroxyphenylboronic acid (0.104 g, 0.76 mmol) and potassium carbonate (0.245 g, 1.78 mmol) were suspended in DME:H2O (2:1, 3 mL). The suspension was purged with N2 (g) for 5 minutes then tetrakis(triphenylphosphine)palladium(0) (0.058 g, 0.051 mmol) was added and the N2 (g) purge continued for 5 additional minutes. The reaction vessel was sealed and heated to 80° C. for 1 hour then allowed to cool. The reaction mixture was submitted to EtOAc/H2O workup then purified on silica gel to yield the title compound.

1. customThe suspension was purged with N2 (g) for 5 minutes
2. customthe N2 (g) purge
3. customThe reaction vessel was sealed
4. temperatureto cool
5. customthen purified on silica gel