Bis(2-Methoxyethyl)amine → 2-Amino-5-{4-[bis-(2-methoxy-ethyl)-carbamoyl]-phenyl}-N-pyridin-4-yl-nicotinamide

HRID 919266Notes

Reaction equation

HRID 919266 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:16]=[CH:15][C:11]([C:12](O)=[O:13])=[CH:10][CH:9]=2)=[CH:4][C:3]=1[C:17](=[O:25])[NH:18][C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1.[CH3:26][O:27][CH2:28][CH2:29][NH:30][CH2:31][CH2:32][O:33][CH3:34]>>[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:16]=[CH:15][C:11]([C:12](=[O:13])[N:30]([CH2:31][CH2:32][O:33][CH3:34])[CH2:29][CH2:28][O:27][CH3:26])=[CH:10][CH:9]=2)=[CH:4][C:3]=1[C:17]([NH:18][C:19]1[CH:20]=[CH:21][N:22]=[CH:23][CH:24]=1)=[O:25]

Participants

3

Reactant 2

HCID 2383Bis(2-Methoxyethyl)amineHCID 710614164-[6-Amino-5-(pyridin-4-ylcarbamoyl)-pyridin-3-yl]-benzoic acid

Product 1

HCID 710615162-Amino-5-{4-[bis-(2-methoxy-ethyl)-carbamoyl]-phenyl}-N-pyridin-4-yl-nicotinamide

Procedure

Reaction of 4-[6-amino-5-(pyridin-4-ylcarbamoyl)-pyridin-3-yl]-benzoic acid with bis-(2-methoxy-ethyl)-amine gives “A89”; method 1: HPLC/MS: 1.30 min, [M+H]=450;

Workup

  1. customgives “A89”
  2. custom1.30 min, [M+H]=450

Sources & evidence

ORD record
ord-3b3f1013b2514b29914131c892e3c375
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

Loading…