Hydrochloric Acid → 4-(Methylamino)-3-nitrobenzoic acid

HRID 919283Notes

Reaction equation

HRID 919283 reaction equation
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].[CH3:14][NH2:15].Cl>O>[CH3:14][NH:15][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6329MethylamineHCID 73204-Chloro-3-nitrobenzoic acid

Product 1

HCID 2834754-(Methylamino)-3-nitrobenzoic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
87.5 °C

Procedure

A mixture of 4-chloro-3-nitrobenzoic acid compound of formula-8 (200 g) and 40% solution of methyl amine (660 ml) was taken into autoclave and heated to 85-90° C. and stirred for 5 hours. After completion of the reaction, the reaction mixture was cooled to 25-35° C. Water was added to the reaction mixture and acidified with hydrochloric acid. Filtered the precipitated solid, washed with water and then dried to get title compound.

Workup

  1. customAfter completion of the reaction
  2. temperaturethe reaction mixture was cooled to 25-35° C
  3. filtrationFiltered the precipitated solid
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-be2adc505ff6408bbeb070dfc6418c72
Source dataset
uspto-grants-2016_03
Patent number
US09273030B2

Reaction notes

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