Trifluoroacetic acid → 1374251-00-9

HRID 919649Notes

Reaction equation

HRID 919649 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]2[N:8]([CH:11]3[CH2:16][CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12]3)[N:9]=[CH:10][C:3]=12.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH:13]1[CH2:14][CH2:15][CH2:16][CH:11]([N:8]2[C:4]3=[N:5][CH:6]=[N:7][C:2]([NH2:1])=[C:3]3[CH:10]=[N:9]2)[CH2:12]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67517324HCID 67517324, compound

Product 1

HCID 675176021374251-00-9Yield 129.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the solution of tert-butyl 3-(4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate (700 mg, 2.2 mmol) in CH2Cl2 (10 mL) was added TFA (2 mL). The resulting mixture was stirred at rt for 1 h, and concentrated in vacuo to afford the title compound (620 mg, 100%) which was used without further purification. ESI-MS (M+H′): 219.0.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-6465ce7c41184295a3f0b21adbb27d29
Source dataset
uspto-grants-2016_03
Patent number
US09273028B2

Reaction notes

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