Trifluoroacetic acid → HCID 89533772, compound

HRID 920221Notes

Reaction equation

HRID 920221 reaction equation
[C:1]([O:4][CH2:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:15]=1[CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)(=[O:3])[CH3:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:1]([O:4][CH2:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:15]=1[CH2:14][NH:13][CH2:12][CH2:11]2)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117635545HCID 117635545, compound

Product 1

HCID 89533772HCID 89533772, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a 10 dram vial, added 7-1 (292.5 mg, 0.958 mmol) to DCM (3831 μl) and TFA (958 μl). After 30 min at RT, concentrated to give a clear, colorless oil. Carried crude material forward to subsequent step.

Workup

  1. concentrationconcentrated
  2. customto give a clear, colorless oil

Sources & evidence

ORD record
ord-f1a2604c83ff48758d8aee135ee67694
Source dataset
uspto-grants-2016_03
Patent number
US09273040B2

Reaction notes

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